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pentobarbital will lessen the extent or outcome of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

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pentobarbital will decrease the extent or influence of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers cuts down plasma focus of abemaciclib and its metabolites.

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